Shire is known as one of the world’s fastest growing specialty pharmaceutical companies. Today, it has value around US $5billion and is the third largest pharma company in the UK. It is the market leader in attention deficit and hyperactivity disorder (ADHD) in the United States, as well as having a growing European network and an exciting set of products being developed for launch and marketing in the future. But only 27 years ago was it a tiny business above a shop. How did it become so successful?